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Doripenem

Introduction:

Doripenem is a new carbapenem antibiotic with broad antibacterial spectrum. It is stable with most of β- lactamase, including penicillin, cephalosporins and extended-spectrum enzyme β- lactamases (ESBLs) It is stable with human dehydropeptidase (DHP-1). In vivo it can’t be hydrolyzed by DHP-1 and can be used alone. It has strong antibacterial activity on anaerobic or aerobic Gram-positive and Gram-negative bacteria. Overal, antibacterial activity of Doripenem is equivalent to Imipenem, Mopenem and Etapenem. However, its activity was significantly stronger than Meropenem on Staphylococcus aureus, Pseudomonas aeruginosa and penicillin-resistant Streptococcus pneumoniae.

CAS NO.: 148016-81-3
Chemical Name: (+)-(4r,5s,6s)-6-[(1r)-1-hydro-xyethyl]-4-methyl-7-oxo-3-[[(3s,5s)-5-[(sulfamoylamino)-methyl]-3-pyrrolidinyl]thio]-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
Molecular Formula: C15H24N4O6S2
Molecular Weight: 420.509
Appearance: white to off-white powder
Storage: -20°C

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